Publications

Original Research

Hepatic p63 regulates glucose metabolism by repressing SIRT1.

Author(s): Gonzalez-Rellan MJ, Novoa E, da Silva Lima N, Rodriguez A, Veyrat-Durebex C, Seoane S, Porteiro B, Fondevila MF, Fernandez U, Varela-Rey M, Senra A, Iglesias C, Escudero A, Fidalgo M, Guallar D, Perez-Fernandez R, Prevot V, Schwaninger M, López M, Dieguez C, Coppari R, Frühbeck G, Nogueiras R.
Published in: Gut. 2022 May 17:gutjnl-2021-326620. doi: 10.1136/gutjnl-2021-326620. Epub ahead of print. PMID: 35580962.

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis.

Author(s): Fondevila MF, Fernandez U, Heras V, Parracho T, Gonzalez-Rellan MJ, Novoa E, Porteiro B, Alonso C, Mayo R, da Silva Lima N, Iglesias C, Filliol AA, Senra A, Delgado TC, Woodhoo A, Herrero L, Serra D, Prevot V, Schwaninger M, López M, Dieguez C, Millet O, Mato JM, Cubero FJ, Varela-Rey M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Schwabe RF, Nogueiras R.
Published in: J Hepatol. 2022 Feb 12:S0168-8278(22)00077-0. doi: 10.1016/j.jhep.2022.02.003. Epub ahead of print. PMID: 35167910.

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis.

Author(s): Fondevila MF, Fernandez U, Heras V, Parracho T, Gonzalez-Rellan MJ, Novoa E, Porteiro B, Alonso C, Mayo R, da Silva Lima N, Iglesias C, Filliol AA, Senra A, Delgado TC, Woodhoo A, Herrero L, Serra D, Prevot V, Schwaninger M, López M, Dieguez C, Millet O, Mato JM, Cubero FJ, Varela-Rey M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Schwabe RF, Nogueiras R.
Published in: J Hepatol. 2022 Feb 12:S0168-8278(22)00077-0. doi: 10.1016/j.jhep.2022.02.003. Epub ahead of print. PMID: 35167910.

A functional cerebral endothelium is necessary to protect against cognitive decline.

Author(s): Trigiani LJ, Bourourou M, Lacalle-Aurioles M, Lecrux C, Hynes A, Spring S, Fernandes DJ, Sled JG, Lesage F, Schwaninger M, Hamel E.
Published in: J Cereb Blood Flow Metab. 2022 Jan;42(1):74-89. doi: 10.1177/0271678X211045438. Epub 2021 Sep 13. PMID: 34515549; PMCID: PMC8721775.

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.

Author(s): da Silva Lima N, Fondevila MF, Nóvoa E, Buqué X, Mercado-Gómez M, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MDP, Bravo SB, Marañon P, Senra A, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, Montero-Vallejo R, Ampuero J, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Prevot V, Gallego-Duran R, Romero-Gomez M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R.
Published in: J Hepatol. 2022 Jan;76(1):11-24. doi: 10.1016/j.jhep.2021.09.008. Epub 2021 Sep 21. PMID: 34555423.

Short regulatory DNA sequences to target brain endothelial cells for gene therapy.

Author(s): Grasshoff H, Müller-Fielitz H, Dogbevia GK, Körbelin J, Bannach J, Vahldieck CM, Kusche-Vihrog K, Jöhren O, Müller OJ, Nogueiras R, Prevot V, Schwaninger M.
Published in: J Cereb Blood Flow Metab. 2022 Jan;42(1):104-120. doi: 10.1177/0271678X211039617. Epub 2021 Aug 24. PMID: 34427142; PMCID: PMC8721777.

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.

Author(s): Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M.
Published in: Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. PMID: 34675436; PMCID: PMC8553622.

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.

Author(s): Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Prévot V.
Published in: Nat Metab. 2021 Aug;3(8):1071-1090. doi: 10.1038/s42255-021-00432-5. Epub 2021 Aug 2. PMID: 34341568; PMCID: PMC7611554.

Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.

Author(s): Lhomme T, Clasadonte J, Imbernon M, Fernandois D, Sauve F, Caron E, da Silva Lima N, Heras V, Martinez-Corral I, Mueller-Fielitz H, Rasika S, Schwaninger M, Nogueiras R, Prevot V.
Published in: J Clin Invest. 2021 Sep 15;131(18):e140521. doi: 10.1172/JCI140521. PMID: 34324439; PMCID: PMC8439611.

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

Author(s): Sandin ES, Folberth J, Müller-Fielitz H, Pietrzik CU, Herold E, Willnow TE, Pfluger PT, Nogueiras R, Prevot V, Krey T, Schwaninger M.
Published in: Int J Mol Sci. 2021 May 8;22(9):4998. doi: 10.3390/ijms22094998. PMID: 34066779; PMCID: PMC8125945.

Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner. Redox Biol.

Author(s): Quiñones M, Hernández-Bautista R, Beiroa D, Heras V, Torres-Leal FL, Lam BYH, Senra A, Fernø J, Gómez-Valadés AG, Schwaninger M, Prevot V, Yeo G, Claret M, López M, Diéguez C, Al-Massadi O, Nogueiras R.
Published in: Redox Biol. 2021 May;41:101945. doi: 10.1016/j.redox.2021.101945. Epub 2021 Mar 13. PMID: 33744652; PMCID: PMC8005845.

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points.

Author(s): Fondevila MF, Mercado-Gómez M, Rodríguez A, Gonzalez-Rellan MJ, Iruzubieta P, Valentí V, Escalada J, Schwaninger M, Prevot V, Dieguez C, Crespo J, Frühbeck G, Martinez-Chantar ML, Nogueiras R.
Published in: J Hepatol. 2021 Feb;74(2):469-471. doi: 10.1016/j.jhep.2020.09.027. Epub 2020 Oct 20. PMID: 33096086; PMCID: PMC7574841.

Hypothalamic bile acid-TGR5 signaling protects from obesity.

Author(s): Castellanos-Jankiewicz A, Guzmán-Quevedo O, Fénelon VS, Zizzari P, Quarta C, Bellocchio L, Tailleux A, Charton J, Fernandois D, Henricsson M, Piveteau C, Simon V, Allard C, Quemener S, Guinot V, Hennuyer N, Perino A, Duveau A, Maitre M, Leste-Lasserre T, Clark S, Dupuy N, Cannich A, Gonzales D, Deprez B, Mithieux G, Dombrowicz D, Bäckhed F, Prevot V, Marsicano G, Staels B, Schoonjans K, Cota D.
Published in: Cell Metab. 2021 Jul 6;33(7):1483-1492.e10. doi: 10.1016/j.cmet.2021.04.009. Epub 2021 Apr 21. PMID: 33887197.

O-GlcNAcylated p53 in the liver modulates hepatic glucose production.

Author(s): Gonzalez-Rellan MJ, Fondevila MF, Fernandez U, Rodríguez A, Varela-Rey M, Veyrat-Durebex C, Seoane S, Bernardo G, Lopitz-Otsoa F, Fernández-Ramos D, Bilbao J, Iglesias C, Novoa E, Ameneiro C, Senra A, Beiroa D, Cuñarro J, Dp Chantada-Vazquez M, Garcia-Vence M, Bravo SB, Da Silva Lima N, Porteiro B, Carneiro C, Vidal A, Tovar S, Müller TD, Ferno J, Guallar D, Fidalgo M, Sabio G, Herzig S, Yang WH, Cho JW, Martinez-Chantar ML, Perez-Fernandez R, López M, Dieguez C, Mato JM, Millet O, Coppari R, Woodhoo A, Fruhbeck G, Nogueiras R.
Published in: Nat Commun. 2021 Aug 20;12(1):5068. doi: 10.1038/s41467-021-25390-0. PMID: 34417460; PMCID: PMC8379189.

GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.

Author(s): Pellegrino G, Martin M, Allet C, Lhomme T, Geller S, Franssen D, Mansuy V, Manfredi-Lozano M, Coutteau-Robles A, Delli V, Rasika S, Mazur D, Loyens A, Tena-Sempere M, Siepmann J, Pralong FP, Ciofi P, Corfas G, Parent AS, Ojeda SR, Sharif A, Prevot V.
Published in: Nat Neurosci. 2021 Dec;24(12):1660-1672. doi: 10.1038/s41593-021-00960-z. Epub 2021 Nov 18. PMID: 34795451.

The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis.

Author(s): Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R.
Published in: Hepatology. 2021 Feb;73(2):606-624. doi: 10.1002/hep.31290. Epub 2020 Nov 13. PMID: 32329085; PMCID: PMC7894478.

Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease.

Author(s): Jiang Y, Müller K, Khan MA, Assmann JC, Lampe J, Kilau K, Richter M, Kleint M, Ridder DA, Hübner N, Schmidt-Supprian M, Wenzel J, Schwaninger M.
Published in: J Cereb Blood Flow Metab. 2021 Feb;41(2):219-235. doi: 10.1177/0271678X20910522. Epub 2020 Mar 9. PMID: 32151223; PMCID: PMC8369998.

NF-κB signaling in tanycytes mediates inflammation-induced anorexia.

Author(s): Böttcher M, Müller-Fielitz H, Sundaram SM, Gallet S, Neve V, Shionoya K, Zager A, Quan N, Liu X, Schmidt-Ullrich R, Haenold R, Wenzel J, Blomqvist A, Engblom D, Prevot V, Schwaninger M.
Published in: Mol Metab. 2020 Sep;39:101022. doi: 10.1016/j.molmet.2020.101022. Epub 2020 May 21. PMID: 32446877; PMCID: PMC7292913.

MCH Neurons Regulate Permeability of the Median Eminence Barrier.

Author(s): Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC.
Published in: Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13. PMID: 32407670; PMCID: PMC7383232.

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.

Author(s): Wenzel J, Hansen CE, Bettoni C, Vogt MA, Lembrich B, Natsagdorj R, Huber G, Brands J, Schmidt K, Assmann JC, Stölting I, Saar K, Sedlacik J, Fiehler J, Ludewig P, Wegmann M, Feller N, Richter M, Müller-Fielitz H, Walther T, König GM, Kostenis E, Raasch W, Hübner N, Gass P, Offermanns S, de Wit C, Wagner CA, Schwaninger M.
Published in: Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1753-1761. doi: 10.1073/pnas.1907467117. Epub 2020 Jan 2. PMID: 31896584; PMCID: PMC6983400.

Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain.

Author(s): Wenzel J, Spyropoulos D, Assmann JC, Khan MA, Stölting I, Lembrich B, Kreissig S, Ridder DA, Isermann B, Schwaninger M.
Published in: Brief Report. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2837-2844. doi: 10.1161/ATVBAHA.120.315061. Epub 2020 Oct 8. PMID: 33028093.

Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa.

Author(s): Florent V, Baroncini M, Jissendi-Tchofo P, Lopes R, Vanhoutte M, Rasika S, Pruvo JP, Vignau J, Verdun S, Johansen JE, Pigeyre M, Bouret SG, Nilsson IAK, Prevot V.
Published in: Neuroendocrinology. 2020;110(6):552-562. doi: 10.1159/000503147. Epub 2019 Sep 5. PMID: 31484186.

Hypothalamic dopamine signaling regulates brown fat thermogenesis.

Author(s): Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, Barja-Fernández S, Gallego R, Hernández-Bautista R, Castelao C, Senra A, Seoane P, Gómez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-García JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Frühbeck G, Seoane LM, Nogueiras R.
Published in: Nat Metab. 2019 Aug;1(8):811-829. doi: 10.1038/s42255-019-0099-7. Epub 2019 Aug 19. PMID: 31579887; PMCID: PMC6774781.

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance.

Author(s): Al-Massadi O, Quiñones M, Clasadonte J, Hernandez-Bautista R, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, García-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R.
Published in: Diabetes. 2019 Dec;68(12):2210-2222. doi: 10.2337/db19-0029. Epub 2019 Sep 16. PMID: 31530579; PMCID: PMC6868473.

Central nicotine induces browning through hypothalamic κ opioid receptor.

Author(s): Seoane-Collazo P, Liñares-Pose L, Rial-Pensado E, Romero-Picó A, Moreno-Navarrete JM, Martínez-Sánchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-García JL, Nogueiras R, Domingos AI, Fernández-Real JM, Rahmouni K, Diéguez C, López M.
Published in: Nat Commun. 2019 Sep 6;10(1):4037. doi: 10.1038/s41467-019-12004-z. PMID: 31492869; PMCID: PMC6731305.

Review/Commentaries

Sowing SARS-CoV-2 to reap neurodegeneration: A hamster study.

Author(s): Rasika S, Fernandois D, Prévot V.
Published in: EBioMedicine. 2022 May 25;80:104071. doi: 10.1016/j.ebiom.2022.104071. Epub ahead of print. PMID: 35633617; PMCID: PMC9132570

The polygamous GnRH neuron: Astrocytic and tanycytic communication with a neuroendocrine neuronal population.

Author(s): Prevot V, Sharif A.
Published inJ Neuroendocrinol. 2022 Feb 6:e13104. doi: 10.1111/jne.13104. Epub ahead of print. PMID: 35233849.

Glycemic control: Tanycytes march to the beat of the suprachiasmatic drummer.

Author(s): Imbernon M, Dehouck B, Prevot V.
Published inCurr Biol. 2022 Feb 28;32(4):R173-R176. doi: 10.1016/j.cub.2022.01.038. PMID: 35231413.

Les neurones produisant l’hormone de mélano-concentration régulent la fenestration des anses vasculaires de l’éminence médiane [MCH neurons regulate fenestration of the median eminence vascular loops reaching the arcuate nucleus of the hypothalamus].

Author(s): Sicardi A, Prévot V.
Published in: Med Sci (Paris). 2022 Mar;38(3):248-251. French. doi: 10.1051/medsci/2022016. Epub 2022 Mar 25. PMID: 35333160.

Glial control of neuronal function.

Author(s): Prevot V.
Published in: Nat Rev Endocrinol. 2022 Apr;18(4):195. doi: 10.1038/s41574-022-00640-3. PMID: 35115720.

Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis.

Author(s): Al-Massadi O, Dieguez C, Schneeberger M, López M, Schwaninger M, Prevot V, Nogueiras R.
Published in: Nat Rev Endocrinol. 2021 Dec;17(12):745-755. doi: 10.1038/s41574-021-00559-1. Epub 2021 Oct 4. PMID: 34608277.

Parvocellular Oxytocin Neurons and Autism Spectrum Disorders.

Author(s): Sundaram SM, Schwaninger M.
Published in: Trends Endocrinol Metab. 2021 Apr;32(4):195-197. doi: 10.1016/j.tem.2021.01.004. Epub 2021 Feb 2. PMID: 33546964.

MECHANISMS IN ENDOCRINOLOGY: The gut-brain axis: regulating energy balance independent of food intake.

Author(s): Nogueiras R.
Published in: Eur J Endocrinol. 2021 Aug 3;185(3):R75-R91. doi: 10.1530/EJE-21-0277. PMID: 34260412; PMCID: PMC8345901.

GnRH Neurons: The Return of the Rat.

Author(s): Martinez-Corral I, Prevot V.
Published in: Endocrinology. 2021 Jan 1;162(1):bqaa207. doi: 10.1210/endocr/bqaa207. PMID: 33159199.

Nicotine’s actions on energy balance: Friend or foe?

Author(s): Seoane-Collazo P, Diéguez C, Nogueiras R, Rahmouni K, Fernández-Real JM, López M.
Published in: Pharmacol Ther. 2021 Mar;219:107693. doi: 10.1016/j.pharmthera.2020.107693. Epub 2020 Sep 26. PMID: 32987056.

Brain JNK and metabolic disease.

Author(s): Nogueiras R, Sabio G.
Published in: Diabetologia. 2021 Feb;64(2):265-274. doi: 10.1007/s00125-020-05327-w. Epub 2020 Nov 16. PMID: 33200240.

Reproductive Function During Chronodisruption: Model of Shiftwork in Rodents.

Author(s): Leysen V, Prevot V.
Published in: Endocrinology. 2020 Dec 1;161(12):bqaa151. doi: 10.1210/endocr/bqaa151. PMID: 32853386; PMCID: PMC7640781.

L’IRM hypothalamique, un nouvel outil diagnostique dans l’anorexie mentale ? [Hypothalamic MRI, a new diagnostic tool in anorexia nervosa?].

Author(s): Florent V, Baroncini M, Prévot V.
Published in: Med Sci (Paris). 2020 Feb;36(2):115-117. French. doi: 10.1051/medsci/2020007. Epub 2020 Mar 4. PMID: 32129746

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation.

Author(s): Müller-Fielitz H, Schwaninger M.
Published in: Exp Clin Endocrinol Diabetes. 2020 Jun;128(6-07):388-394. doi: 10.1055/a-1065-1855. Epub 2019 Dec 11. PMID: 31860118.

Book Chapters

Tanycytes in the infundibular nucleus and median eminence and their role in the blood-brain barrier.

Author(s): Prevot V, Nogueiras R, Schwaninger M.
Published in: Handb Clin Neurol. 2021;180:253-273. doi: 10.1016/B978-0-12-820107-7.00016-1. PMID: 34225934.

Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery

Author(s): Sreekala Nampoothiri, Manon Duquenne, Vincent Prevot
Published in: Glial-Neuronal Signaling in Neuroendocrine Systems, Issue 11, 2021, Page(s) 255-284
DOI: 10.1007/978-3-030-62383-8_11

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